Conor Harrington's Dance with the Devil (2013) is estimated to make £30,000-50,000 ($45,369-75,615) in Bonhams' Founded sale in London on January 28.
Harrington began his career as a street artist whose large-scale paintings grace walls around the world, from Bristol to Bethlehem.
He tends to focus on historical themes as shown in the present lot, which depicts two men engaged in a duel.
The piece is executed in oil and spray paint and forms part of the artist's acclaimed L'amour et la Violence series.
A set of 84 drawings by British artist Cecily Brown is another highlight, with an identical valuation of £30,000-50,000 ($45,369-75,615).
The collection is inspired by the erotic illustrations of the old masters, but offers a female perspective.
Bonhams comments: "Brown depicts a sexuality informed by the mores and morals of the late 20th Century influenced by the harsh, sometimes brutal imagery of modern pornography."
A work by Peter Doig, Lion in the Sand M-16, is likely to prove another highlight, with a £5,000-7,000 ($7,561-10,586) estimate.
The piece was painted on a decommissioned assault rifle for the M16 exhibition at London's Frieze Art Fair.
A total of 15 rifles were modified by well-known artists, including Jeremy Deller and the Chapman brothers, and all will be auctioned in the sale to benefit anti-war charity Peace One Day.
Please sign up to our free newsletter to receive exciting news about art and antiques auctions.